Machine learning / Single-cell genomics / Cell fate

Junyao Jiang 蒋俊尧

Computational Biologist at Westlake University, developing machine learning and single-cell/spatial genomics methods to decode cell fate decisions, reconstruct fate-resolved regulatory networks, and map developmental programs across species and tissues.

Publications Landscape Archive
Google Scholar ORCID

I am also an amateur bodybuilder with 140KG maximal weight for bench press, 190KG maximal weight for Deadlift, and 170KG maximal weight for Squat.

Main research topic

From DeepTrack barcoding to transferable fate maps.

  • Cell fate decisions explain how pluripotent cells develop into diverse tissues, and how disruptions can lead to congenital abnormalities.
  • In vivo single-cell multi-omics lineage tracing has enabled early lineage priming discovery in mouse embryos and fate-resolved GRN reconstruction.
  • Because direct genetic barcoding is ethically and technically infeasible in human embryos, transfer learning can provide non-invasive in silico fate mapping from 3D human embryo data.
Research framework overview

Professional path

Professional Experience in Computational Biology

  • Incoming Postdoctoral Researcher at DANDRITE
  • 2022.08 - 2026.06 Ph.D. in Biology, Systems and Synthetic Biology Program, Westlake University
  • 2021.03 - 2022.06 Research Assistant, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
  • 2020.12 - 2021.02 Bioinformatician Intern, Singleron Biotech
  • 2020.12 - 2021.02 M.Sc. in Genomics and Bioinformatics, Chinese University of Hong Kong

Publications

Featured publications

* Co-first author. # Corresponding author.

Nature Cell Biology / Major revision In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

Chenyu Guo*, Junyao Jiang*, Xiaomin Wang*, Xinghuai Huang, Shenghu Zhang, Chenyang Shao, Mingyuan Zhang, Xiwen Hu, Wenqian Yang, Fuwei Shang, Xi Wang, Hongbo Zhai, Quan Du, Fang Liu, Danyang He, Xiaodong Liu, Guangdun Peng, Saifeng Cheng, Yanxiao Zhang#, Duanqing Pei#, Weike Pei#

Co-first author

Single-cell multi-omics lineage tracing / Mouse embryogenesis / Fate-resolved GRN / Cell atlas

Nature / Major revision Uncovering the origins and functional features of hematopoiesis in extramedullary organs

Uncovering the origins and functional features of hematopoiesis in extramedullary organs

Wenqian Yang*, Zhexuan Hu*, Junyao Jiang*, Chenyu Guo*, Zongcheng Li*, Weipeng Ge, Yizhen Chu, Qi Shi, Xiaotong Wang, Xinghuai Huang, Xiwen Hu, Hui Li, Huayu Pan, Fuwei Shang, Zheng Wang, Xi Wang, Fang Liu, Quan Du, Hongbo Zhai, Heping Xu, Danyang He, Yu Lan#, Bing Liu#, Weike Pei#

Co-first author

Lineage tracing / Extramedullary hematopoiesis / EPO

Other publications

  1. Yunhui Kong*, Junyao Jiang*#, Weikang Kong, Sheng Qin#. DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms. Communications Biology, Sep 2024. Co-first author and corresponding author.
  2. Ying Xin, Pin Lyu, Junyao Jiang, Fengquan Zhou, Jie Wang, Seth Blackshaw, Jiang Qian. LRLoop: Feedback loops as a design principle of cell-cell communication. Bioinformatics, July 2022.
  3. Dapeng Sun*, Xiaojie Gan*, Lei Liu*, Yuan Yang*, Dongyang Ding, Wen Li, Junyao Jiang, et al. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Cell Death & Disease, May 2022.

Recognition

Awards

Doctoral National Scholarship, 2024.10. Top 1% PhD student in China.

Mentorship

Research mentoring

  • Xing Ye: Undergraduate from University of Science and Technology of China, 2023.11-2024.06. Co-first author at scLTdb project.
  • Zhi Chen: Undergraduate from Tsinghua University, 2025.07-2025.08. Summer research program.
  • Jiayi Liu: MSc from Imperial College London, Research Assistant, 2025.10-Present.

Peer review

Journal service

  • Nature (Co-Review)
  • Nature Cell Biology (Co-Review)
  • Communications Biology
  • Archives of Computational Methods in Engineering
  • BMC Bioinformatics
  • BMC Genomics
  • Scientific Reports