About
I am a Ph.D Candidate in Biology (Computional Biology) at the School of Life Sciences, Westlake University. I was a former Research Assistant from Jie Wang Lab at Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences.
My research focus primarily revolves around the application of statistical and machine learning methods to omics data, specifically single-cell and spatial genomics. I have developed several computational approaches to decipher gene regulations and cross-species conservation. Additionally, I am eager to analyze complex omics data to gain insights into embryonic development and the heterogeneity of cancer.
I am also an amateur bodybuilder with 125KG maximal weight for bench press, 180KG maximal weight for Deadlift, and 170KG maximal weight for Squat.
Research Keywords: single cell & spatial genomics, machine learning, system biology
Research experience in Bioinformatics/Comp Bio
Ph.d Candidate in Biology (Computional Biology) at Westlake University. 2022.08-present (I will comment this experience after i earn PHD degree (if possible?))
- Apply machine learning and statistic methods on single cell multiomics & spatial genomics data
- Using single cell lineage tracing technolog to study embroy development
- ……
Research Assistant at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. 2021.03-2022.06 (Get computational biology training here, with great gratitude to Professor Jie Wang)
- Develop IReNA to reconstruct GRN based on single cell multiomics data
- Develop CACIMAR to perform cross-species analysis based on scRNA-seq data
- Analyze DNA methylation and scRNA-seq data to study hepatic carcinoma.
Bioinformatician Intern at Singleron Biotech. 2020.12-2021.02 (Just run pipeline, boring……)
- Integrate large scale public scRNA-seq data to evaluate PBMC immu cell functions
- Develop fast single cell multiomics data analysis pipeplines.
Master in Genomics & Bioinformatics at Chinese University of Hong Kong. 2020.09-2021.11 (Where my bioinformatics journey begin)
- Analyze whole genome sequencing data to study bacteria evolution
- Analyze bulk and single cell RNA-seq data to study hepatic carcinoma, advised by Prof TSUI Kwok Wing.
Selected Publications
*: co-first, #: correspondence
 | scLTdb: a comprehensive single cell lineage tracing database |
 | CACIMAR: cross-species analysis of cell identities, markers, regulations, and interactions using single-cell RNA sequencing data |
 | IReNA: Integrated Regulatory Network Analysis of Single-Cell Transcriptomes and Chromatin Accessibility Profiles |
Other Publications
Yunhui Kong*, Junyao Jiang*,#, Weikang Kong, Sheng Qin#. DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms. Communications Biology, Sep 2024 (Co-first & Co-correspondence)
Ying Xin*, Pin Lyu*, Junyao Jiang, Fengquan Zhou, Jie Wang, Seth Blackshaw, Jiang Qian. LRLoop: Feedback loops as a design principle of cell-cell communication. Bioinformatics, July 2022
Dapeng Sun*, Xiaojie Gan*, Lei Liu*, Yuan Yang*, Dongyang Ding, Wen Li, Junyao Jiang, et al. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Cell Death & Disease, May 2022
Maintained Software
- IReNA Consturct gene regualtory networks based on single cell multiomics data
- CACIMAR scRNA-seq based cross-species data analysis
- FateMapper single cell lineage tracing data analysis and visualization
- scLTdb Database for single cell lineage tracing
Mentorship
Xing Ye: Undergraduate from University of Science and Technology of China, 2023.11-2024.06. (Co-first author at scLTdb project)